HIVdent.org | Oral Manifestations

Last Updated: September 5, 2023

*Featured Articles*

John Greenspan, BDS, PhD: 1938 – 2023 Dr. Greenspan's research career spanned more than five decades and included numerous groundbreaking discoveries in the field of oral medicine. He was particularly interested in the relationship between oral health and HIV/AIDS, and his work helped establish the field of oral HIV/AIDS research. Throughout his career and until the very end of his life, Dr. Greenspan remained a devoted teacher and mentor, inspiring and guiding generations of dental and medical investigators. He supervised or mentored over 120 physicians and dental scientists. He was generous with his guidance and advice to those he mentored. Courtesy of: University of California San Francisco \| School of Dentistry


	Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: a cross sectional study BMC Oral Health. 2023 Aug 27;23(1):600. doi: 10.1186/s12903-023-03330-2.
	HIV: Early Signs A Person May Notice Inside The Mouth Opera News \| August 11, 2023
	Human Papillomavirus-Related Oropharyngeal Cancer Prevention: The Critical Role of Dental and Medical Professionals Medscape \| July 11, 2023
	An Appreciation of a Giant in Orofacial Sciences Research-John Greenspan J Dent Res. 2023 Jul 14;220345231181536. doi: 10.1177/00220345231181536.
	Signs of Common Head and Neck Cancers WebMD
	HAART treatment for HIV/Aids patients plays key role in their oral health Dental Tribune \| May 30, 2023
	John Greenspan \| British Dental Journal Nature \| May 26, 2023
	Combination Therapy of Oral Valacyclovir and Topical Clobetasol Is the Most Effective in Herpes Labialis Management J Evid Based Dent Pract; April 20, 2023
	Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma J Clin Med; 2022 Nov 29; 11 (23)7061; S Blatt, M Krüger, K Sagheb, et al
	Linear Gingival Erythema and HIV: Symptoms, Treatment Verywell Health \| November 4, 2022
	Researchers receive $3.25 million NIH grant to better understand the oral manifestations of HIV News-Medical.net \| July 11, 2022
	Candidiasis and HIV: Link, treatment, and prevention Medical News Today \| June 17, 2022
	Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults Tumour Virus Res. 2022 Apr 20;200237. doi: 10.1016/j.tvr.2022.200237
	The influence of antiretroviral therapy on HIV-related oral manifestations Journal of the National medical Association \| December 2021
	What Your Tongue (and Mouth) Can Tell You About Your Health AARP \| October 8, 2021
	HPV vaccinations will slow oropharynx cancer rates but may take 25 years to see impact Healio \| September 8, 2021
	Human papillomavirus (HPV) and Oropharyngeal Cancer
	Mouth Problems and HIV
	Improving Access to Oral Health Care for Vulnerable and Underserved Populations
	Genital, Oral, and Anal Human Papillomavirus Infection in Men Who Have Sex with Men
	Oral Manifestations Of HIV/AIDS In The HAART ERA By David A. Reznik, D.D.S. and Christine O’Daniels, RN-BC\|
	A Case-Based Self-Study Module For Dental Health Care Personnel Mountain Plains AIDS Education and Training Center
	Management of Dental Patients Who Are HIV Positive
	Oral Manifestation Of HIV Infection By Drs. Deborah Greenspan and John S. Greenspan

*Research News*
	Characterization of oral candidiasis according to antiretroviral treatment status, immunological and virological profiles among HIV infected patients in two... Pan Afr Med J. 2023 May 15;45:33. doi: 10.11604/pamj.2023.45.33.33714. eCollection 2023
	Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda Viruses. 2023 Apr 19;15(4):1005. doi: 10.3390/v15041005
	Bibliometric Analysis of Poor Oral Health as a Risk Factor for Oral Cancer Cureus \| March 11, 2023
	A comparative study on the production of extracellular hydrolytic enzymes of C. albicans and non- albicans Candida species isolated from... Curr Med Mycol. 2022 Jun;8(2):32-39. doi: 10.18502/cmm.8.2.10330.
	Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral... PLoS One. 2022 Jul 5;17(7):e0270876. doi: 10.1371/journal.pone.0270876. eCollection 2022.
	Epidemiology and Prevalence of Oral Candidiasis in HIV Patients From Chad in the Post-HAART Era Front Microbiol. 2022 Feb 17;13:844069. doi: 10.3389/fmicb.2022.844069. eCollection 2022
	Oral HPV associated with differences in oral microbiota beta diversity and microbiota abundance J Infect Dis. 2022 Jan 17;jiac010. doi: 10.1093/infdis/jiac010.
	Prevalence of oral lesions in patients with AIDS: a systematic review and meta-analysis Evid Based Dent. 2021 Nov 10. doi: 10.1038/s41432-021-0209-8
	Drug resistance in Candida albicans isolates and related changes in the structural domain of Mdr1 protein J Infect Public Health. 2021 Nov 4;S1876-0341(21)00363-4. doi: 10.1016/j.jiph.2021.11.002.
	Oral and anal carriage of Streptococcus pneumoniae among sexually active men with HIV who have sex with men J Infect Dis. 2021 Oct 8;jiab512. doi: 10.1093/infdis/jiab512.
	HIV-Associated Interactions Between Oral Microbiota and Mucosal Immune Cells: Knowledge Gaps and Future Directions Front Immunol. 2021 Sep 20;12:676669. doi: 10.3389/fimmu.2021.676669. eCollection 2021.

*News Updates*
	Plasmablastic Lymphoma in a Human Immunodeficiency Virus-positive Child With a Suspicion of Concomitant Primary Immunodeficiency... NIH \| July 26, 2023
	Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways NPJ Biofilms Microbiomes. 2023 Jul 12;9(1):48. doi: 10.1038/s41522-023-00413-4
	Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the... NIH \| PubMed \| July 2023
	Patient Living with Human Immunodeficiency Virus with Gingival Pain and Oral Soreness (Red and White Lesions) Dent Clin North Am. 2023 Jul;67(3):495-498. doi: 10.1016/j.cden.2023.02.028. Epub 2023 Mar 25.
	ADA Gold Medal winner who pioneered oral AIDS research died at 85 American Dental Association \| April 26, 2023
	Oropharyngeal Secondary Syphilis Mimicking Metastatic Lymphoma in an HIV-Positive Patient Cureus \| April 24, 2023
	Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH... Cancer. 2023 Apr 9. doi: 10.1002/cncr.34783
	Continuing Education Can Engage Dental Health Professionals in Promoting HPV Vaccination J Public Health Dent; 2023 Mar 9; EPub Ahead of Print; N Askelson, G Ryan, S McKernan, et al
	Discourse about human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) on Twitter: Lessons for public health education about OPC and dental care
	Characterization of Oral Microbiota in Patients With HPV and Non-HPV HNSCC and Association With Outcomes Oral Oncol \| January 4, 2023
	A systematic review of four decades of prevalence of oral soft tissue infections and conditions among adult HIV patients in India J Family Med Prim Care. 2022 Jul;11(7):3407-3413. doi: 10.4103/jfmpc.jfmpc_1191_21.
	Lower Risk Of Head And Neck Cancer DrBicuspid \| October 31, 2022
	Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus J Otolaryngol Head Neck Surg. 2022 Oct 4;51(1):37. doi: 10.1186/s40463-022-00586-6.
	State-of-the-Science Concepts of HPV-Related Oropharyngeal Squamous Cell Carcinoma Practice Update \| September 29, 2022
	State-of-the-Science Concepts of HPV-Related Oropharyngeal Squamous Cell Carcinoma Oral Surg Oral Med Oral Pathol Oral Radiol; 2022 Aug 1; 134 (2)190-20
	Exposing the Great Imitator: Proposal for a Holistic Diagnosis of Oral Secondary Syphilis in People Living with HIV Head Neck Pathol. 2022 Sep;16(3):773-784. doi: 10.1007/s12105-022-01446-5. Epub 2022 Mar 25.
	HIV: initial symptoms in women and men Emergency Live \| August 12, 2022
	Unexpected plasmablastic lymphoma in a young adult with unknown HIV infection: case report J Gastrointest Oncol. 2022 Jun;13(3):1467-1472. doi: 10.21037/jgo-21-779.
	Mucoadhesive Nucleoside-Based Hydrogel Delays Oral Leukoplakia Canceration Mar 31, 2022 \| OnlineFirst
	Influence of Topical Corticosteroids on Malignant Transformation of Oral Lichen Planus Journal of Oral Pathology & Medicine \| March 30, 2022
	Mucormycosis Cases Associated with COVID-19 Appear in the United States, Other Countries Infectious Disease Special Edition \| January 24, 2022
	Oral cancer: prevention and early diagnosis D1SoftballNews.com \| January 1, 2022
	Oropharyngeal Cancer Incidence and Mortality Trends in the US, 2001–2017 JAMA Otolaryngol Head Neck Surg; 2021 Dec 16; EPub
	BRIEF REPORT Oral versus extra-oral plasmablastic lymphoma: a comparative analysis of 101 cases J Oral Pathol Med. 2021 Dec 15. doi: 10.1111/jop.13269.
	HIV symptoms: Early signs may include mouth ulcers or sores Daily Express \| December 1, 2021
	The applicability of ultrasound in the diagnosis of inflammatory and obstructive diseases of the major salivary glands: a scoping review Dentomaxillofac Radiol. 2021 Nov 11. doi: 10.1259/dmfr.20210361.
	Can Dehydration Cause “White Tongue?” Symptoms, Treatment Healthline \| September 23, 2021
	Oral 'black fungus' infection linked to COVID-19 treatment Dr Bicuspid \| September 22, 2021

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Front Immunol. 2021 Sep 20;12:676669. doi: 10.3389/fimmu.2021.676669. eCollection 2021.