Last Updated: February 16, 2024    


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John Greenspan, BDS, PhD: 1938 – 2023

Dr. Greenspan's research career spanned more than five decades and included numerous groundbreaking discoveries in the field of oral medicine. He was particularly interested in the relationship between oral health and HIV/AIDS, and his work helped establish the field of oral HIV/AIDS research.

Throughout his career and until the very end of his life, Dr. Greenspan remained a devoted teacher and mentor, inspiring and guiding generations of dental and medical investigators. He supervised or mentored over 120 physicians and dental scientists. He was generous with his guidance and advice to those he mentored.


Courtesy of: University of California San Francisco | School of Dentistry


Clinical Assessment and Management in Improving the Quality of Life of | HIV

Dove Medical Press | November 13, 2023

Risk indicators for oral ulcers among people living with HIV during the first wave of the pandemic: a cross sectional study 

BMC Oral Health. 2023 Aug 27;23(1):600. doi: 10.1186/s12903-023-03330-2.

HIV: Early Signs A Person May Notice Inside The Mouth

Opera News | August 11, 2023

Human Papillomavirus-Related Oropharyngeal Cancer Prevention: The Critical Role of Dental and Medical Professionals

Medscape | July 11, 2023

An Appreciation of a Giant in Orofacial Sciences Research-John Greenspan 

J Dent Res. 2023 Jul 14;220345231181536. doi: 10.1177/00220345231181536.

Signs of Common Head and Neck Cancers


HAART treatment for HIV/Aids patients plays key role in their oral health

Dental Tribune | May 30, 2023

John Greenspan | British Dental Journal

Nature | May 26, 2023

Combination Therapy of Oral Valacyclovir and Topical Clobetasol Is the Most Effective in Herpes Labialis Management

J Evid Based Dent Pract; April 20, 2023

Tumor Recurrence and Follow-Up Intervals in Oral Squamous Cell Carcinoma

J Clin Med; 2022 Nov 29; 11 (23)7061; S Blatt, M Krüger, K Sagheb, et al

Linear Gingival Erythema and HIV: Symptoms, Treatment

Verywell Health | November 4, 2022

Researchers receive $3.25 million NIH grant to better understand the oral manifestations of HIV | July 11, 2022

Candidiasis and HIV: Link, treatment, and prevention

Medical News Today | June 17, 2022

Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults 

Tumour Virus Res. 2022 Apr 20;200237. doi: 10.1016/j.tvr.2022.200237

The influence of antiretroviral therapy on HIV-related oral manifestations

Journal of the National medical Association | December 2021

What Your Tongue (and Mouth) Can Tell You About Your Health

AARP | October 8, 2021

HPV vaccinations will slow oropharynx cancer rates but may take 25 years to see impact

Healio | September 8, 2021

Human papillomavirus (HPV) and Oropharyngeal Cancer
Mouth Problems and HIV
Improving Access to Oral Health Care for Vulnerable and Underserved Populations
Genital, Oral, and Anal Human Papillomavirus Infection in Men Who Have Sex with Men
Oral Manifestations Of HIV/AIDS In The HAART ERA
By David A. Reznik, D.D.S. and Christine O’Daniels, RN-BC|
A Case-Based Self-Study Module For Dental Health Care Personnel
Mountain Plains AIDS Education and Training Center
Management of Dental Patients Who Are HIV Positive
Oral Manifestation Of HIV Infection
By Drs. Deborah Greenspan and John S. Greenspan
Research News

Characterization of oral candidiasis according to antiretroviral treatment status, immunological and virological profiles among HIV infected patients in two... 

Pan Afr Med J. 2023 May 15;45:33. doi: 10.11604/pamj.2023.45.33.33714. eCollection 2023

Prevalence of Human Papillomavirus in Different Mucous Membranes in HIV Concordant Couples in Rwanda 

Viruses. 2023 Apr 19;15(4):1005. doi: 10.3390/v15041005

Bibliometric Analysis of Poor Oral Health as a Risk Factor for Oral Cancer

Cureus | March 11, 2023

A comparative study on the production of extracellular hydrolytic enzymes of C. albicans and non- albicans Candida species isolated from...

Curr Med Mycol. 2022 Jun;8(2):32-39. doi: 10.18502/cmm.8.2.10330.

Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral...

PLoS One. 2022 Jul 5;17(7):e0270876. doi: 10.1371/journal.pone.0270876. eCollection 2022.

Epidemiology and Prevalence of Oral Candidiasis in HIV Patients From Chad in the Post-HAART Era 

Front Microbiol. 2022 Feb 17;13:844069. doi: 10.3389/fmicb.2022.844069. eCollection 2022

Oral HPV associated with differences in oral microbiota beta diversity and microbiota abundance 

J Infect Dis. 2022 Jan 17;jiac010. doi: 10.1093/infdis/jiac010.

Prevalence of oral lesions in patients with AIDS: a systematic review and meta-analysis 

Evid Based Dent. 2021 Nov 10. doi: 10.1038/s41432-021-0209-8

Drug resistance in Candida albicans isolates and related changes in the structural domain of Mdr1 protein 

J Infect Public Health. 2021 Nov 4;S1876-0341(21)00363-4. doi: 10.1016/j.jiph.2021.11.002.

Oral and anal carriage of Streptococcus pneumoniae among sexually active men with HIV who have sex with men 

J Infect Dis. 2021 Oct 8;jiab512. doi: 10.1093/infdis/jiab512.

HIV-Associated Interactions Between Oral Microbiota and Mucosal Immune Cells: Knowledge Gaps and Future Directions 

Front Immunol. 2021 Sep 20;12:676669. doi: 10.3389/fimmu.2021.676669. eCollection 2021.

News Updates

The Association Between Oral Mucosal Lesions and Oral Health-Related Quality of Life Using the Validated Indonesian Version of OHIP-14 Among...

Dovepress | February 8, 2024

Mucocutaneous histoplasmosis as the first manifestation of AIDS

NIH | February 6, 2024

Oral Herpes: Causes, Symptoms, & Treatment

WebMD | January 29, 2024

Antifungal Susceptibility and Candida sp. Biofilm Production in Clinical Isolates of HIV-Positive Brazilian Patients under HAART Therapy

MDPI | January 29, 2024

Unveiling the Unspoken: Exploring Oral Manifestations of Psychological Disorders

Cureus | January 25, 2024

Primary manifestation of HIV-related Burkitt lymphoma in the oral and maxillofacial regions

NIH | January 2024

Immune indices and oral health in patients infected with the human immunodeficiency virus

NIH | December 15, 2023

Prevalence and Predictors of Oral Treponema pallidum Detection by qPCR in Early Syphilis 

J Infect Dis. 2023 Dec 21:jiad582. doi: 10.1093/infdis/jiad582

Save the Date: Clinical Manifestations of HIV/AIDS and Opportunistic Infections

AETC | December 15, 2023

Oral health-related quality of life after rehabilitation with maxillary obturators: A comparison of patients with maxillectomy defects associated...

NIH | December 15, 2023

Castleman’s Disease With Tongue Lesions in an HIV-Positive Patient From Saudi Arabia

Cureus | December 8, 2023

Adjunctive phototherapies for oral manifestation of HIV-related histoplasmosis and leishmaniasis: An unusual case report

Science Direct | December 2023

Clinical Assessment and Management in Improving the Quality of Life of HIV/AIDS Patients with Oral Candidiasis: A Case Series

NIH | November 14, 2023

Relationship between Salivary Cytokines and HIV-Oral Lesions among Newly Diagnosed Adults with HIV in Southwest Nigeria

ScienceDirect | November 2023

Hydroxychloroquine Is Safe and Effective for the Management of Oral Lichen Planus 

Oral Dis | November 9, 2023

The value of regular follow-up of oral leukoplakia for early detection of malignant transformation

Wiley Online Library | November 7, 2023

Impact of Drug Use on Oral Health: Drugs That Cause Dental Problems

American Addiction Centers | September 22, 2023

Oral Manifestations - Core Concepts

National HIV Curriculum | September 6, 2023

How HIV Can Affect the Tongue

Verywell health | September 3, 2023

Plasmablastic Lymphoma in a Human Immunodeficiency Virus-positive Child With a Suspicion of Concomitant Primary Immunodeficiency...

NIH | July 26, 2023

Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways 

NPJ Biofilms Microbiomes. 2023 Jul 12;9(1):48. doi: 10.1038/s41522-023-00413-4

Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the...

NIH | PubMed | July 2023

Patient Living with Human Immunodeficiency Virus with Gingival Pain and Oral Soreness (Red and White Lesions) 

Dent Clin North Am. 2023 Jul;67(3):495-498. doi: 10.1016/j.cden.2023.02.028. Epub 2023 Mar 25.

ADA Gold Medal winner who pioneered oral AIDS research died at 85 

American Dental Association | April 26, 2023

Oropharyngeal Secondary Syphilis Mimicking Metastatic Lymphoma in an HIV-Positive Patient 

Cureus | April 24, 2023

Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH...

Cancer. 2023 Apr 9. doi: 10.1002/cncr.34783

Continuing Education Can Engage Dental Health Professionals in Promoting HPV Vaccination 

J Public Health Dent; 2023 Mar 9; EPub Ahead of Print; N Askelson, G Ryan, S McKernan, et al

Discourse about human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) on Twitter: Lessons for public health education about OPC and dental care

Characterization of Oral Microbiota in Patients With HPV and Non-HPV HNSCC and Association With Outcomes 

Oral Oncol | January 4, 2023

A systematic review of four decades of prevalence of oral soft tissue infections and conditions among adult HIV patients in India

J Family Med Prim Care. 2022 Jul;11(7):3407-3413. doi: 10.4103/jfmpc.jfmpc_1191_21.

Lower Risk Of Head And Neck Cancer

DrBicuspid | October 31, 2022

Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human immunodeficiency virus 

J Otolaryngol Head Neck Surg. 2022 Oct 4;51(1):37. doi: 10.1186/s40463-022-00586-6.

State-of-the-Science Concepts of HPV-Related Oropharyngeal Squamous Cell Carcinoma 

Practice Update | September 29, 2022

State-of-the-Science Concepts of HPV-Related Oropharyngeal Squamous Cell Carcinoma 

Oral Surg Oral Med Oral Pathol Oral Radiol; 2022 Aug 1; 134 (2)190-20

Exposing the Great Imitator: Proposal for a Holistic Diagnosis of Oral Secondary Syphilis in People Living with HIV 

Head Neck Pathol. 2022 Sep;16(3):773-784. doi: 10.1007/s12105-022-01446-5. Epub 2022 Mar 25.

HIV: initial symptoms in women and men

Emergency Live | August 12, 2022

Unexpected plasmablastic lymphoma in a young adult with unknown HIV infection: case report

J Gastrointest Oncol. 2022 Jun;13(3):1467-1472. doi: 10.21037/jgo-21-779.

Mucoadhesive Nucleoside-Based Hydrogel Delays Oral Leukoplakia Canceration

Mar 31, 2022 | OnlineFirst

Influence of Topical Corticosteroids on Malignant Transformation of Oral Lichen Planus 

Journal of Oral Pathology & Medicine | March 30, 2022

Mucormycosis Cases Associated with COVID-19 Appear in the United States, Other Countries

Infectious Disease Special Edition | January 24, 2022

Oral cancer: prevention and early diagnosis | January 1, 2022

Oropharyngeal Cancer Incidence and Mortality Trends in the US, 2001–2017 

JAMA Otolaryngol Head Neck Surg; 2021 Dec 16; EPub

BRIEF REPORT Oral versus extra-oral plasmablastic lymphoma: a comparative analysis of 101 cases 

J Oral Pathol Med. 2021 Dec 15. doi: 10.1111/jop.13269.

HIV symptoms: Early signs may include mouth ulcers or sores

Daily Express | December 1, 2021

The applicability of ultrasound in the diagnosis of inflammatory and obstructive diseases of the major salivary glands: a scoping review 

Dentomaxillofac Radiol. 2021 Nov 11. doi: 10.1259/dmfr.20210361.

Can Dehydration Cause “White Tongue?” Symptoms, Treatment

Healthline | September 23, 2021

Oral 'black fungus' infection linked to COVID-19 treatment

Dr Bicuspid | September 22, 2021


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