Revi Nelonda, Irna Sufiawati, Tenny Setiani Dewi
Department of Oral Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia
Objectives: To determine the relationship between xerostomia and low salivary flow rates in HIV/AIDS patients who had received ARV therapy and had a low CD4 cell count.
Methods: The type of research was cross-sectional. The research subjects were HIV/AIDS patients. Xerostomia was measured using the Fox et.al questionnaire which has been tested for validity and reliability. Salivary flow rate was measured using the spitting method. The relationship between xerostomia and salivary flow rate with the use of ARV was analyzed by Chi-Square test and the relationship with CD4 was analyzed by Fisher Exact and Mann Whitney test.
Results: The subject of the study involved 34 HIV/AIDS patients, consisting of 73.5% men and 26.5% women, with 50% treated with ARV. As many as 52.6% of subjects experiencing xerostomia had a median CD4 of 309 cells/ mm3 and as many as 53.3% of subjects had a salivary flow rate of 0.1-0.2 ml/minute a median CD4 of 261 cells/mm3 had taken ARV. The ARV used was a combination of Azidothymine such as nevirapine, tenofovir, efavirenz, lamivudine, and stavudine. Statistically, results showed that xerostomia and hyposalivation were not significantly associated with the use of ART and CD4 in HIV/AIDS patients (p> 0.05).
Conclusions: Xerostomia and hyposalivation were not significantly associated with ARV and CD4 counts in HIV/AIDS patients. Further study with larger sample sizes are needed, looking at other factors that can cause xerostomia in HIV patients.