Oral Manifestations

 

Oral Ulcers and Necrotizing Gingivitis In Relation to HIV-Associated Neutropenia: A Review and An Illustrative Case

 
 

Oral Ulcers and Necrotizing Gingivitis In Relation to HIV-Associated Neutropenia: A Review and An Illustrative Case
AIDS Res Hum Retroviruses. 2011 Jul 6


Feller L, Khammissa RA, Wood NH, Meyerov R, Pantanowitz L, Lemmer J
Medunsa Oral Health Centre, Periodontology and Oral Medicine, Pretoria, Gauteng, South Africa; liviu.feller@ul.ac.za

Abstract

An unusual case of necrotizing gingivitis and neutropenic oral ulcers in an HIV-seropositive patient is presented. In spite of a very low CD4+ T cell count and severe neutropenia, the necrotizing gingivitis responded favourably to standard periodontal treatment, and the oral ulcers healed after administration of granulocyte-colony stimulating factor (G-CSF). Non-specific oral ulcers in HIV-seropositive subjects with neutropenia should be regarded as neutropenic ulcers. The term non-specific ulcers should be restricted to those ulcers with non-specific histopathological features in patients without neutropenia or a nutritional deficiency such as iron, folic acid and vitamin B.


 
 
 
     
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